" Hello I am a cheater cock..... Oh Plz I am not Malignant!!" My take on GCT

Benign tumor
Dorsum of tongue most common site of occurrence
appears as nodule
H/P mimics SCC with pseudoepitheliomatous hyperplasia with syncytium of granular cells
Oh no.... u should still search for my parents !!!! origin unknown------- Muscle outdated, neural- under study

local excision would suffice, uncommon recurrence
very rarely malignant transformation

Backdrop:

Also known as Abrikossoff’s tumour
 
Ref:
 http://www.hindawi.com/journals/isrn/2011/215251/

Classification of Granular cell lesions: 

(I)Odontogenic:

(1)granular cell ameloblastoma,
(2)central and peripheral granular cell odontogenic tumor/granular cell Ameloblastic fibroma/central granular cell odontogenic fibroma,
(3)calcifying epithelial odontogenic tumor,
(4)granular cell odontogenic cyst (variant of lateral periodontal cyst).

(II)Nonodontogenic neoplasms:

(A)Soft tissue neoplasms:

(a)Benign:

(1)granular cell tumor,
(2)congenital epulis of newborn,
(3)leiomyoma,
(4)rhabdomyoma,
(5)neurilemmoma,
(6)granular cell traumatic neuroma,
(7)paraganglioma,
(8)dermatofibroma,
(9)perivascular epithelioid cell tumor.

(b)Malignant:
(1)alveolar soft part sarcoma,
(2)malignant granular cell tumor,
(3)rhabdomyosarcoma,
(4)hodgkin’s lymphoma,
(5)basal cell carcinoma,
(6)angiosarcoma,
(7)dermatofibrosarcoma.

(B)Salivary gland diseases (oncocytic lesions):

(a)Benign neoplasms:
(1)Warthin’s tumor,
(2)Oncocytoma,
(3)canalicular adenoma

(b)Malignant neoplasms:
(1)acinic cell carcinoma,
(2)mucoepidermoid carcinoma,
(3)epithelial-myoepithelial carcinoma,
(4)oncocytic carcinoma,
(5)salivary duct carcinoma.

(c)Nonneoplastic lesions:
(1)sialadenosis,
(2)oncocytosis.

(C)Melanocytic lesions:
(1)pigmented basal cell carcinoma,
(2)malignant melanoma,
(3)naevus,
(4)melanocytic macule.

(D)Histiocytic lesions:
(1)Langerhans cell histiocytosis,
(2)verruciform xanthoma,
(3)xanthogranuloma,
(4)atypical fibroxanthoma.

(E)Reactive lesions:
(1)gingival hyperplasia,
(2) traumatic sites.

(F)Metastatic lesions:
(1)granular cell variant of renal cell carcinoma,
(2)metastasis from carcinoma of breast,
(3)metastatic malignant melanoma,
(4)metastatic oncocytic carcinoma of thyroid,
(5)metastatic hepatocellular carcinoma.

(G)Miscellaneous:
(1)fibrous papule of the nose,
(2)granular cell lichen planus.

Pseudoepitheliomatous hyperplasia--- MY LIST 1

1. Necrotizing sialometaplasia

2. Granular cell tumor

3. Keratoacanthoma

4. Epulis fissuratum

5. Inflammatory papillary hyperplasia

6. Central papillary atrophy of tongue

7. Wegener’s granulomatosis

8. Blastomycosis

9. Sporotrichosis

10. Syphilitic tertiary gumma ( peripheral )

11. Pyostomatitis vegetans

12. Granuloma inguinale

13. PLGA